The metabolism of lysergic acid diethylamide.
نویسنده
چکیده
The unavailability of a suitable preanaesthetic medicament is discussed. A double blind comparison of placebo, meprobamate and pentobarbital as preanaesthetic medicants for regional procedures is presented. The authors have determined the effects of each of these treatments on patient's apprehension, cooperation, drowsiness, reaction to painful stimuli, talkativeness, nausea and emesis. The anaesthetist's evaluation of the adequency of each premedicant has also been determined. Both, meprobamate and pentobarbital have been found to be more effective than placebo. The difference is well marked in younger group of patients but tends to be less marked with advancing age and may disappear in the senile group. No significant difference has been found between meprobamate and pentobarbital in doses employed.
منابع مشابه
The effects of D-lysergic acid diethylamide on cerebral circulation and overall metabolism.
متن کامل
Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
BACKGROUND The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice. METHODS We characterized the pharmacokinetic profile, pharmacokinetic-pharmacodynamic relationship, and urine recovery of lysergic acid diethylamide and its main metabolite after administration of a single oral...
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D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); E.C. 4.6.1.1] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the histamine H2-receptor. Both D-lysergic acid diethylamide and D-2-bromolysergic ac...
متن کاملMechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.
Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lyse...
متن کاملThe distribution and metabolism of lysergic acid diethylamide.
Although lysergic acid diethylamide (LSD), the hallucinogenic agent, has been the subject of numerous investigations, little is known about its biologic fate. In recent studies Boyd et al.’ and St011 el ~1.2 have examined the tissue distribution of CL4-labeled LSD in mice. Stoll and his co-workers2 have shown that the Cr4-labeled material measured in tissues included LSD, as well as transformat...
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ورودعنوان ژورنال:
- Archives internationales de pharmacodynamie et de therapie
دوره 120 شماره
صفحات -
تاریخ انتشار 1959